So you just got your SDDC deployed and the VPN is connected and you can ping your on-prem hosts from the cloud SDDC but you are unable to connect to them via HTTP or HTTPS. Make sure you have opened firewall ports on in the VMware Cloud on AWS Portal. If it still does not work, this may be due to a setting on your Cisco ASA firewall called Maximum Segment Size.
ciscoasa(config)# sysopt connection tcpmss 8500 ciscoasa(config)# sysopt connection tcpmss minimum 1290
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